Telomere Shortening in Cancer and Aging

Miguel GODINHO FERREIRA, Research Director, DR2 CNRS
  • For full publication list, please go to:
  • Telomere shortening produces an inflammatory environment that increases tumor incidence in zebrafish

    Lex K, Maia Gil M, Lopes-Bastos B, Figueira M, Marzullo M, Giannetti K, Carvalho T, Ferreira MG

    Proc Natl Acad Sci U S A. pii: 201920049. doi: 10.1073/pnas.1920049117.

    PMID: 32554492

  • Opposing p53 and mToR/AKT promote an in vivo switch from apotosis to senescence upon telomere shortening in zebrafish

    El Maï M, Marzullo M, de Castro IP, Ferreira MG.

    Elife. 2020 May 19;9. pii: e54935. doi: 10.7554/eLife.54935.

    PMID: 32427102
  • The Zebrafish as an Emerging Model to Study DNA Damage in Aging, Cancer and Other Diseases.

    Cayuela ML, Claes KBM, Ferreira MG, Henriques CM, van Eeden F, Varga M, Vierstraete J, Mione MC.
    Frontiers in cell and developmental biology. 2019; 6:178.
    PMID: 30687705

  • Ssu72 phosphatase is a conserved telomere replication terminator

    Escandell JM, Carvalho ES, Gallo-Fernandez M, Reis CC, Matmati S, Luís IM, Abreu IA, Coulon S, Ferreira MG.

    The EMBO journal. 2019;

    PMID: 30796050
  • Using zebrafish PDX to screen drug sensitivity of endocrine-dependent cancers.

    Fior R, Ferreira MG.
    Proceedings of the National Academy of Sciences of the United States of America. 2018; 115(13):E2910.
    PMID: 29531074

  • FoxM1 repression during human aging leads to mitotic decline and aneuploidy-driven full senescence.

    Macedo JC, Vaz S, Bakker B, Ribeiro R, Bakker PL, Escandell JM, Ferreira MG, Medema R, Foijer F, Logarinho E.

    Nature communications. 2018; 9(1):2834.

    PMID: 30026603
  • Single-cell functional and chemosensitive profiling of combinatorial colorectal therapy in zebrafish xenografts.

    Fior R, Póvoa V, Mendes RV, Carvalho T, Gomes A, Figueiredo N, Ferreira MG.

    Proceedings of the National Academy of Sciences of the United States of America. 2017; 114(39):E8234-E8243.

    PMID: 28835536
  • Short Telomeres in Key Tissues Initiate Local and Systemic Aging in Zebrafish.

    Carneiro MC, Henriques CM, Nabais J, Ferreira T, Carvalho T, Ferreira MG.
    PLoS genetics. 2016; 12(1):e1005798.
    PMID: 26789415

  • Telomeres in aging and disease: lessons from zebrafish.

    Carneiro MC, de Castro IP, Ferreira MG.

    Disease models & mechanisms. 2016; 9(7):737-48.

    PMID: 27482813
  • TERT promoter mutations in pancreatic endocrine tumours are rare and mainly found in tumours from patients with hereditary syndromes.

    Vinagre J, Nabais J, Pinheiro J, Batista R, Oliveira RC, Gonçalves AP, Pestana A, Reis M, Mesquita B, Pinto V, Lyra J, Cipriano MA, Ferreira MG, Lopes JM, Sobrinho-Simões M, Soares P.

    Scientific reports. 2016; 6:29714.

    PMID: 27411289
  • Sowing the seeds of cancer: telomeres and age-associated tumorigenesis.

    Pereira B, Ferreira MG.

    Current opinion in oncology. 2013; 25(1):93-8.

    PMID: 23211840
  • Telomerase is required for zebrafish lifespan.

    Henriques CM, Carneiro MC, Tenente IM, Jacinto A, Ferreira MG.

    PLoS genetics. 2013; 9(1):e1003214.

    PMID: 23349637
  • Consequences of telomere shortening during lifespan.

    Henriques CM, Ferreira MG.

    Current opinion in cell biology. 2012; 24(6):804-8.

    PMID: 23127607
Research teams