Open positions
 

Véronique PAQUIS-FLUCKLINGER, Professor-Clinician, PU-PHCE
November 2021
3-year post-doctoral position

A postdoctoral position (one year renewable 2 times) is available in the team of Pr Véronique Paquis-Flucklinger at IRCAN Institute (UMR CNRS 7284 INSERM U1081 Université Côte d’Azur) to investigate the mechanisms of action and in vivo proof of concept of drugs for treating mitochondrial diseases. Mainly based on a repositioning drug strategy, the efficacy of compounds will be tested in iPSC and mouse models generated in the team, with as final goal to prepare a clinical trial. The successful applicant will be working in the research team at IRCAN Institute in collaboration with the Reference Center for Mitochondrial Diseases at Nice University Hospital.

We welcome enquiries from prospective applicants with a good background in mitochondrial research. Ideal candidate will have PhD in Biological Sciences and an experience in work with mice and/or iPSCs. The project being mainly targeted on the cardiomyopathies observed in these pathologies, background in the analysis of cardiac phenotypes would be an additional asset.

 

Application should contain CV together with the names and addresses of two referees and should be sent by e-mail to: This email address is being protected from spambots. You need JavaScript enabled to view it.

 

The date of taking up office is scheduled during the first months of 2022.

 

References

- Genin EC et al. Mitochondrial defect in muscle precedes neuromuscular junction degradation and motor neuron death in CHCHD10S59L/+ mouse. Acta Neuropathol, 2019; 138:123-145.

- Genin EC et al. CHCHD10 mutations promote loss of mitochondrial cristae junctions with defect in mitochondrial genome maintenance and apoptosis. EMBO Mol Med 2015 ; Dec 14;8(1):58-72. doi: 10.15252/emmm.201505496.

- Bannwarth S et al. A mitochondrial origin for frontotemporal dementia and amyotrophic lateral sclerosis through CHCHD10 involvement. Brain 2014; 137:2329-45