Open positions
 

Eric RÖTTINGER, Research Director, DR2 CNRS
May 2022
Postdoctoral research position available to investigate the origin of neuronal cancers

An INCa-funded postdoctoral position for a collaborative project with the Centre Scientifique de Monaco (CSM) is available in the Röttinger lab at the Institute for Research on Cancer and Aging in Nice (IRCAN).

This call is for a 12 months postdoctoral contrat (funding secured)

To apply: https://emploi.cnrs.fr/Offres/CDD/UMR7284-ERIROT-003/Default.aspx?lang=EN

Job description: The successful candidate will work in an international and interdisciplinary environment and conduct research to decipher the molecular signals involved in the dysregulation of neuronal precursors that may lead to the development of pediatric cancers. In the context of the present position, the candidate will spearhead the development of the sea anemone Nematostella vectensis as a novel and complementary pediatric research model. This project is part of a transborder collaboration between France (IRCAN) and Monaco (CSM), supported by the National Cancer Institute (INCa - PEDIAHR21-010) that aims at investigating the concept of oncogene in embryonal neuronal tumors using unconventional approaches. She/he will be responsible for the coordination of the research axis of the project in tight interaction with the collaborators from the Centre Scientifique de Monaco (CSM), fellow lab members working on complementary projects and under the direct supervision of the PI. This includes all aspects of tasks associated to the project, e.g. animal care, wet-lab experimentation and data analysis/interpretation. Within the year, she/he is strongly encouraged to submit proposals to national and international funding agencies to secure additional funds and extend the postdoctoral position.

Qualifications: We are looking for a strongly motivated, enthusiastic and creative researcher with the following qualifications, skills and expertise:

Required qualifications:
- PhD degree (obtained before starting date)
- Strong scientific background in cellular or developmental biology
- Evidence of fluent English communication (oral/written)
- Evidence of scientific rigor, organizational skills and team spirit
- Strong publication record in peer-reviewed journals
- Draft and contribute to the writing of scientific manuscripts

Desirable qualifications:
- Experience in functional genomics and associated approaches (e.g. Crispr/Cas9, light-sheet microscopy, Transcriptomics)
- Scientific background in neuronal developmental biology
- Experience in animal (marine invertebrate) care and experimentation
- Experience in bioinformatics
- Success in securing external funding

Gross salary: 2 690 et 3 993 € / month depending on the level of experience

Start date: The position is available now

Location: Université Côte d'Azur - School of Medicine - IRCAN (CNRS, INSERM, UCA) | Nice, France

www.ircan.org/en/research/eric-rottinger

To Apply: https://emploi.cnrs.fr/Offres/CDD/UMR7284-ERIROT-003/Default.aspx?lang=EN

Call is open until June 30, 2022 or until position is filled.

Eric RÖTTINGER, Research Director, DR2 CNRS
November 2021
3-year post-doctoral position

A postdoctoral position (one year renewable 2 times) is available in the team of Pr Véronique Paquis-Flucklinger at IRCAN Institute (UMR CNRS 7284 INSERM U1081 Université Côte d’Azur) to investigate the mechanisms of action and in vivo proof of concept of drugs for treating mitochondrial diseases. Mainly based on a repositioning drug strategy, the efficacy of compounds will be tested in iPSC and mouse models generated in the team, with as final goal to prepare a clinical trial. The successful applicant will be working in the research team at IRCAN Institute in collaboration with the Reference Center for Mitochondrial Diseases at Nice University Hospital.

We welcome enquiries from prospective applicants with a good background in mitochondrial research. Ideal candidate will have PhD in Biological Sciences and an experience in work with mice and/or iPSCs. The project being mainly targeted on the cardiomyopathies observed in these pathologies, background in the analysis of cardiac phenotypes would be an additional asset.

 

Application should contain CV together with the names and addresses of two referees and should be sent by e-mail to: This email address is being protected from spambots. You need JavaScript enabled to view it.

 

The date of taking up office is scheduled during the first months of 2022.

 

References

- Genin EC et al. Mitochondrial defect in muscle precedes neuromuscular junction degradation and motor neuron death in CHCHD10S59L/+ mouse. Acta Neuropathol, 2019; 138:123-145.

- Genin EC et al. CHCHD10 mutations promote loss of mitochondrial cristae junctions with defect in mitochondrial genome maintenance and apoptosis. EMBO Mol Med 2015 ; Dec 14;8(1):58-72. doi: 10.15252/emmm.201505496.

- Bannwarth S et al. A mitochondrial origin for frontotemporal dementia and amyotrophic lateral sclerosis through CHCHD10 involvement. Brain 2014; 137:2329-45