Stress Response, regeneration & longevity

Eric RÖTTINGER, Research Director, DR2 CNRS
  • Articulating the “stem cell niche” paradigm through the lens of non-model aquatic invertebrates

    Martinez P, Ballarin L, Ereskovsky A, Gazave E, Hobmayer B, Manni L, Röttinger E, Sprecher GS, Tiozzo S, Varela-Coelho A, Rinkevich B

    BMC Biology, Jan 20, 20:23


  • Intrinsically high capacity of animal cells from a symbiotic cnidarian to deal with pro-oxidative conditions

    Cotinat P, Fricano C, Toullec G, Röttinger E, Barnay-Verdier S, Furla P

    Frontiers in Physiology, in press


  • Guidelines for creating a user-friendly and open-access gene expression database for comparing embryonic development and regeneration in Nematostella vectensis

    Olivier Croce & Röttinger E

    Methods in Molecular Biology. Editor: Brigitte Galliot & Simon Blanchoud, in press


  • Nematostella vectensis, an emerging model for deciphering the molecular and cellular mechanisms underlying whole-body regeneration

    Röttinger E

    Cells, Oct 8;10(10):2692

    PMID: 34685672

  • A pan-metazoan concept for adult stem cells: The wobbling Penrose landscape

    Rinkevich B, Ballarin L, Martinez P, Somorjai I, Ben-Hamo O, Borisenko I, Berezikov E, Ereskovsky A, Gazave E, Khnykin D, Manni L, Petukhova O, Rosner A, Röttinger E, Spagnuolo A, Sugni M, Tiozzo, S, Hobmayer, B

    Biological reviews, 2021 Oct 6.  doi: 10.1111/brv.12801

    PMID: 34617397

  • Un trio de mécanismes au cœur de l’initiation de la régénération chez les animaux

    Vullien A, Röttinger E, Vervoort M et Gazave E

    Médecine / Sciences, 37:349 - 358

    PMID: 33908852

  • L’anémone de mer Nematostella vectensis, un modèle émergent pour la recherche biomédicale : mécano-sensibilité, régénération et longévité

    Amiel RA, Michel V, Carvalho EJ, Shkreli M, Petit C & Röttinger E. 

    Médecine / Sciences, 37:167–177

    PMID: 33591260

  • The essentials of marine biotechnology

    Rotter A & COST Ocean4Biotech Consortium.

    Frontiers in Marine Science, March 16;8:629629

    Link to publication

  • Stem cells of aquatic invertebrates as an advanced tool for assessing ecotoxicological impacts

    Rosnera A, Armengaudb J, Ballarin L, Barnay-Verdier S, Cima F, Varela-Coelhoe A, Domart-Coulonf I, Drobneg D, Genevière AM, Kokalj AJ, Kotlarska E, Lyons DM, Mass T, Paza G, Pazdro K, Perić L, Ramšak A, Rakers S, Rinkevich B, Spagnuolo A, MichelaSugni M, Cambier S

    Sci Total Environ. 2021 Jun 1;771:144565

    PMID: 33736145

  • Cryopreserved cnidarian cells: A powerful tool for cell-culture based functional assays

    Fricano C, Röttinger E, Furla P & Barnay-Verdier S.

    Cells, Nov 26;9(12):2541

    PMID: 33256018

  • Horizontal acquisition of Symbiodiniaceae in the Anemonia viridis (Cnidaria, Anthozoa) species complex

    Porro B, Zamoum T, Mallien C, Hume BCC, Voolstra CR, Röttinger E, Furla P & Forcioli D.

    Molecular Ecology, 2021;30:391-405

    PMID: 33249664

  • Transcriptomic Analysis in the Sea Anemone Nematostella vectensis

    Warner FJ & Röttinger E

    Methods in Molecular Biology. Editor: David Carroll. 2021;2219:231-240

    PMID: 33074544

  • Experimental tools to study regeneration in the sea anemone Nematostella vectensis

    Amiel RA & Röttinger E

    Methods in Molecular Biology. Editor: David Carroll. 2021;2219:69-80

    PMID: 33074534

  • The diversity of metazoan muscles and their regenerative potential across animals

    Zullo L, Bozzo M, Di Clemente A, Mancini F, Megighian A, Nesher N, Röttinger E, Shomrat T, Tiozzo S, Zullo A, Candiani S. 

    Cells. 9, 2020 Aug 19;9(9):1925

    PMID: 32825163

  • 7th Euro Evo Devo meeting: Report on the "Evolution of regeneration in Metazoa" symposium

    Gazave E, Röttinger E

    J Exp Zool B Mol Dev Evol. 2019 Aug 28.

    PMID: 31461214

  • Next-generation phylogeography of the cockle Cerastoderma glaucum: Highly heterogeneous genetic differentiation in a lagoon species

    Sromek L, Forcioli D, Lasota R, Furla P, Wolowicz M

    Ecol Evol. 2019 Mar 27;9(8):4667-4682

    PMID: 31031934

  • The Tara Pacific expedition: A pan-ecosystemic approach of the "-omics" complexity of coral reef holobionts across the Pacific Ocean

    Planes S, Allemand D, Agostini S, Banaigs B, Boissin E, Boss E, Bourdin G, Bowler C, Douville E, Flores JM, Forcioli D, Furla P, Galand PE, Ghiglione JF, Gilson E, Lombard F, Moulin C, Pesant S, Poulain J, Reynaud S, Romac S, Sullivan MB, Sunagawa S, Thomas OP, Troublé R, de Vargas C, Vega Thurber R, Voolstra CR, Wincker P, Zoccola D; Tara Pacific Consortium.

    PLoS Biol. 2019 Sep 23;17(9):e3000483. doi: 10.1371/journal.pbio.3000483. [Epub ahead of print]

    PMID: 31545807

  • Expanding Tara Oceans Protocols for Underway, Ecosystemic Sampling of the Ocean-Atmosphere Interface During Tara Pacific Expedition (2016–2018)

    Gabriel Gorsky, Guillaume Bourdin, Fabien Lombard, Maria Luiza Pedrotti, Samuel Audrain, Nicolas Bin, Emmanuel Boss, Chris Bowler, Nicolas Cassar, Loic Caudan, Genevieve Chabot, Natalie R. Cohen, Daniel Cron, Colomban De Vargas, John R. Dolan, Eric Douville, Amanda Elineau, J. Michel Flores, Jean Francois Ghiglione, Nils Haëntjens, Martin Hertau, Seth G. John, Rachel L. Kelly, Ilan Koren, Yajuan Lin, Dominique Marie, Clémentine Moulin, Yohann Moucherie, Stéphane Pesant, Marc Picheral, Julie Poulain, Mireille Pujo-Pay, Gilles Reverdin, Sarah Romac, Mathew B. Sullivan, Miri Trainic, Marc Tressol, Romain Troublé, Assaf Vardi, Christian R. Voolstra, Patrick Wincker, Sylvain Agostini, Bernard Banaigs, Emilie Boissin, Didier Forcioli, Paola Furla, Pierre E. Galand, Eric Gilson, Stéphanie Reynaud, Shinichi Sunagawa, Olivier P. Thomas, Rebecca Lisette Vega Thurber, Didier Zoccola, on behalf of Tara Pacific Consortium, Serge Planes, Denis Allemand and Eric Karsenti.

    Frontiers in Marine Science, 11 December 2019

    Doi: 10.3389/fmars.2019.00750

  • The many faced symbiotic snakelocks anemone (Anemonia viridis, Anthozoa): Host and symbiont genetic differentiation among colour morphs

    Porro B, Mallien C, Hume BCC, Pey A, Aubin E, Christen R, Voolstra CR, Furla P, Forcioli D.

    Heredity. 2019 Sep 16.

    PMID: 31527783

  • How does an animal behave like a plant? Physiological and molecular adaptations of zooxanthellae and their hosts to symbiosis

    Allemand D, Furla P.

    C R Biol. 2018 May - Jun;341(5):276-280.

    PMID: 29650460

  • NvERTx: a gene expression database to compare embryogenesis and regeneration in the sea anemone Nematostella vectensis

    Warner J, Guérlais V, Amiel RA, JohnstonH, Nedoncelle K & Röttinger E


    PMID: 29739837

  • Cnidarian primary cell culture as a tool to investigate the effect of thermal stress at the cellular level

    Ventura P, Toullec G, Fricano C, Chapron L, Meunier V, Röttinger E, Furla P, Barnay-Verdier S.

    Marine Biotechnology. 20(2):144-154

    PMID: 29313151

  • Conspicuous morphological differentiation without speciation in Anemonia viridis (Cnidaria, Actiniaria)

    Mallien C, Porro B, Zamoum T, Olivier C, Wiedenmann J, Furla P & Forcioli D. 

    Systematics and Biodiversity. 16 (3), Issue 3, 271-386. 

  • A bipolar role of the transcription factor ERG for cnidarian germ layer formation and apical domain patterning

    Amiel RA*, Johnston H*, Chock T, Dahlin P, Iglesias M, Layden M, Röttinger E@ & Martindale MQ@

    Dev Biol. 2017 Oct 15;430(2):346-361

    PMID: 28818668

    * co-first, @ co-corresponding

  • A novel technique to combine and analyse spatial and temporal expression datasets: A case study with the sea anemone Nematostella vectensis to identify potential gene interactions

    Abdol AM, Röttinger E, Jansson F, Kaandorp JA.

    Dev Biol. 2017 Jun 8. pii: S0012-1606(17)30100-8.

    PMID: 28602952

  • Diversity of Cnidarian Muscles: Function, Anatomy, Development and Regeneration

    Leclère L, Röttinger E.

    Front Cell Dev Biol. 2017 Jan 23;4:157.

    PMID: 28168188

  • MAPK signaling is necessary for neurogenesis in Nematostella vectensis

    Layden MJ, Johnston H, Amiel AR, Havrilak J, Steinworth B, Chock T, Röttinger E, Martindale MQ.

    BMC Biol. 2016 Aug 1;14:61.

    PMID: 27480076

  • The rise of the starlet sea anemone Nematostella vectensis as a model system to investigate development and regeneration

    Layden MJ, Rentzsch F, Röttinger E.

    Wiley Interdiscip Rev Dev Biol. 2016 Jul;5(4):408-28.

    PMID: 26894563

  • Autophagy : Moving Benchside Promises to Patient Bedsides

    Belaid A, Ndiaye PD, Filippakis H, Roux J, Röttinger E, Graba Y, Brest P, Hofman P, Mograbi B.

    Curr Cancer Drug Targets. 2015;15(8):684-702.

    PMID: 26452384

  • Nodal signaling is required for mesodermal and ventral but not for dorsal fates in the indirect developing hemichordate, Ptychodera flava

    Röttinger E@, DuBuc TQ, Amiel AR, Martindale MQ.

    Biol Open. 2015 May 15;4(7):830-42.

    PMID: 25979707

    @ co-corresponding

  • Analysis of a spatial gene expression database for sea anemone Nematostella vectensis during early development

    Botman D, Jansson F, Röttinger E, Martindale MQ, de Jong J, Kaandorp JA.

    BMC Syst Biol. 2015 Sep 24;9:63.

    PMID: 26400098

  • Domain analysis of the Nematostella vectensis SNAIL ortholog reveals unique nucleolar localization that depends on the zinc-finger domains

    Dattoli AA, Hink MA, DuBuc TQ, Teunisse BJ, Goedhart J, Röttinger E, Postma M.

    Sci Rep. 2015 Jul 20;5:12147.

    PMID: 26190255

  • Characterization of Morphological and Cellular Events Underlying Oral Regeneration in the Sea Anemone, Nematostella vectensis

    Amiel AR, Johnston HT, Nedoncelle K, Warner JF, Ferreira S, Röttinger E.

    Int J Mol Sci. 2015 Dec 1;16(12):28449-71.

    PMID: 26633371

  • Hemichordata

    Kaul-Strehlow S, Röttinger E

    In: Evolutionary Developmental Biology of Invertebrates 6: Deuterostomia

    Editor: Andreas Wanninger. Springer-Verlag GMBH / Vienna, 2015

    DOI 10.1007/978-3-7091-1856-6_2

  • In vivo imaging of Nematostella vectensis embryogenesis and late development using fluorescent probes

    DuBuc TQ, Dattoli AA, Babonis LS, Salinas-Saavedra M, Röttinger E, Martindale MQ, Postma M.

    BMC Cell Biol. 2014 Nov 30;15:44.

    PMID: 25433655

  • A computational approach towards a gene regulatory network for the developing Nematostella vectensis gut

    Botman D, Röttinger E, Martindale MQ, de Jong J, Kaandorp JA.

    PLoS One. 2014 Jul 30;9(7):e103341.

    PMID: 25076223

  • Microinjection of mRNA or morpholinos for reverse genetic analysis in the starlet sea anemone, Nematostella vectensis

    Layden MJ, Röttinger E, Wolenski FS, Gilmore TD, Martindale MQ.

    Nat Protoc. 2013 May;8(5):924-34.

    PMID: 23579781

  • Ex-situ Macro Photography of Marine Life

    Ormestad M., Amiel A., Röttinger E

    In: Imaging Marine Life: Modern Imaging techniques in Marine Biology.

    Editor: Emmanuel G. Reynaud. Wiley VCH / Weinheim, 2013

    DOI: 10.1002/9783527675418.ch9

  • Evolutionary crossroads in developmental biology: hemichordates

    Röttinger E, Lowe CJ.

    Development. 2012 Jul;139(14):2463-75. doi: 10.1242/dev.066712.

    PMID: 22736243

  • Reciprocal signaling between the ectoderm and a mesendodermal left-right organizer directs left-right determination in the sea urchin embryo

    Bessodes N, Haillot E, Duboc V, Röttinger E, Lahaye F, Lepage T.

    PLoS Genet. 2012;8(12):e1003121.

    PMID: 23271979

  • A framework for the establishment of a cnidarian gene regulatory network for "endomesoderm" specification: the inputs of ß-catenin/TCF signaling

    Röttinger E, Dahlin P, Martindale MQ.

    PLoS Genet. 2012;8(12):e1003164.

    PMID: 23300467

  • A comparative gene expression database for invertebrates

    Ormestad M, Martindale MQ, Röttinger E.

    Evodevo. 2011 Aug 24;2:17.

    PMID: 21861937

  • Ancestral regulatory circuits governing ectoderm patterning downstream of Nodal and BMP2/4 revealed by gene regulatory network analysis in an echinoderm

    Saudemont A, Haillot E, Mekpoh F, Bessodes N, Quirin M, Lapraz F, Duboc V, Röttinger E, Range R, Oisel A, Besnardeau L, Wincker P, Lepage T.

    PLoS Genet. 2010 Dec 23;6(12):e1001259.

    PMID: 21203442

  • Centralization of the deuterostome nervous system predates chordates

    Nomaksteinsky M, Röttinger E, Dufour HD, Chettouh Z, Lowe CJ, Martindale MQ, Brunet JF.

    Curr Biol. 2009 Aug 11;19(15):1264-9.

    PMID: 19559615

  • FGF signals guide migration of mesenchymal cells, control skeletal morphogenesis and regulate gastrulation during sea urchin development

    Röttinger E, Saudemont A, Duboc V, Besnardeau L, McClay D, Lepage T.

    Development. 2008 Jan;135(2):353-65. Epub 2007 Dec 12.

    PMID: 18077587

  • Expression pattern of three putative RNA-binding proteins during early development of the sea urchin Paracentrotus lividus

    Röttinger E, Besnardeau L, Lepage T.

    Gene Expr Patterns. 2006 Oct;6(8):864-72.

    PMID: 17061352

  • Nemo-like kinase (NLK) acts downstream of Notch/Delta signalling to downregulate TCF during mesoderm induction in the sea urchin embryo

    Röttinger E, Croce J, Lhomond G, Besnardeau L, Gache C, Lepage T.

    Development. 2006 Nov;133(21):4341-53.

    PMID: 17038519


  • RTK and TGF-beta signaling pathways genes in the sea urchin genome

    Lapraz F, Röttinger E, Duboc V, Range R, Duloquin L, Walton K, Wu SY, Bradham C, Loza MA, Hibino T, Wilson K, Poustka A, McClay D, Angerer L, Gache C, Lepage T.

    Dev Biol. 2006 Dec 1;300(1):132-52.

    PMID: 17084834

  • The genome of the sea urchin Strongylocentrotus purpuratus

    Sodergren E, Weinstock GM, Davidson EH, & Sea Urchin Genome Sequencing Consortium.

    Science. 2006 Nov 10;314(5801):941-52. 

    PMID: 17095691

  • Left-right asymmetry in the sea urchin embryo is regulated by nodal signaling on the right side

    Duboc V, Röttinger E, Lapraz F, Besnardeau L, Lepage T.

    Dev Cell. 2005 Jul;9(1):147-58.

    PMID: 15992548

  • Nodal and BMP2/4 signaling organizes the oral-aboral axis of the sea urchin embryo

    Duboc V, Röttinger E, Besnardeau L, Lepage T.

    Dev Cell. 2004 Mar;6(3):397-410.

    PMID: 15030762

  • A Raf/MEK/ERK signaling pathway is required for development of the sea urchin embryo micromere lineage through phosphorylation of the transcription factor Ets

    Röttinger E, Besnardeau L, Lepage T.

    Development. 2004 Mar;131(5):1075-87.

    PMID: 14973284

Research teams