Telomere, senescence and cancer

Eric GILSON, Director, Professor-Clinician, PU-PHCE
  •   The non-telomeric evolutionary trajectory of TRF2 in zebrafish reveals its specific roles in neurodevelopment and aging.
  • Loss of atm in Zebrafish as a Model of Ataxia-Telangiectasia Syndrome.
    Chen K, Wang P, Chen J, Ying Y, Chen Y, Gilson E, Lu Y, Ye J.
    Biomedicines. 2022 Feb 7;10(2):392. doi: 10.3390/biomedicines10020392. PMID: 35203601
  • Selective pericentromeric heterochromatin dismantling caused by TP53 activation during senescence.

    Mendez-Bermudez A, Lototska L, Pousse M, Tessier F, Croce O, Latrick CM, Cherdyntseva V, Nassour J, Xiaohua J, Lu Y, Abbadie C, Gagos S, Ye J, Gilson

    Nucleic Acids Res. 2022 Jul 22;50(13):7493-7510. doi: 10.1093/nar/gkac603. PMID: 35819196

  •   Telomeres as a sentinel of population decline in the context of global warming.


    Lemaître JF, Gaillard JM, Gilson E. Proc Natl Acad Sci U S A.
    2022 Aug 30;119(35):e2211349119. doi: 10.1073/pnas.2211349119. Epub 2022 Aug 10. PMID: 35947638
  • Multifunctionality of the Telomere-Capping Shelterin Complex Explained by Variations in Its Protein Composition.

     Ghilain C, Gilson E, Giraud-Panis MJ.

    Cells. 2021 Jul 11;10(7):1753. doi: 10.3390/cells10071753. PMID: 34359923

  • Neutrophils: mediating TelOxidation and senescence.

    Jacome Burbano MS, Cherfils-Vicini J, Gilson E.

    EMBO J. 2021 May 3;40(9):e108164. doi: 10.15252/embj.2021108164. Epub 2021 Apr 20. PMID: 33880795

  • The Power of Stress: The Telo-Hormesis Hypothesis.

    Jacome Burbano MS, Gilson E.

    Cells. 2021 May 11;10(5):1156. doi: 10.3390/cells10051156.

  • Long-lived post-mitotic cell aging: is a telomere clock at play?

    Jacome Burbano MS, Gilson E.

    Mech Ageing Dev. 2020 Jul;189:111256. doi: 10.1016/j.mad.2020.111256. Epub 2020 May 4. PMID: 32380018 Review.

  • Heterochromatin replication goes hand in hand with telomere protection.

    Mendez-Bermudez A, Giraud-Panis MJ, Ye J, Gilson E.

    Nat Struct Mol Biol. 2020 Apr;27(4):313-318. doi: 10.1038/s41594-020-0400-1. Epub 2020 Mar 30. PMID: 32231287 Review.

  • Inhibiting TRF1 upstream signaling pathways to target telomeres in cancer cells

    Cherfils-Vicini J, Gilson E.

    EMBO Mol Med. 2019 Jul;11(7):e10845. doi: 10.15252/emmm.201910845. 

    PMID: 31273935

  • TRF2 positively regulates SULF2 expression increasing VEGF-A release and activity in tumor microenvironment.

    Zizza P, Dinami R, Porru M, Cingolani C, Salvati E, Rizzo A, D'Angelo C, Petti E, Amoreo CA, Mottolese M, Sperduti I, Chambery A, Russo R, Ostano P, Chiorino G, Blandino G, Sacconi A, Cherfils-Vicini J, Leonetti C, Gilson E, Biroccio A.

    Nucleic Acids Res. 2019 Jan 30. doi: 10.1093/nar/gkz041

    PMID: 30698737

  • The Tara Pacific expedition: A pan-ecosystemic approach of the "-omics" complexity of coral reef holobionts across the Pacific Ocean

    Planes S, Allemand D, Agostini S, Banaigs B, Boissin E, Boss E, Bourdin G, Bowler C, Douville E, Flores JM, Forcioli D, Furla P, Galand PE, Ghiglione JF, Gilson E, Lombard F, Moulin C, Pesant S, Poulain J, Reynaud S, Romac S, Sullivan MB, Sunagawa S, Thomas OP, Troublé R, de Vargas C, Vega Thurber R, Voolstra CR, Wincker P, Zoccola D; Tara Pacific Consortium.

    PLoS Biol. 2019 Sep 23;17(9):e3000483. doi: 10.1371/journal.pbio.3000483. [Epub ahead of print]

    PMID: 31545807

  • Cancer cells induce immune escape via glycocalyx changes controlled by the telomeric protein TRF2

    Cherfils-Vicini J, Iltis C, Cervera L, Pisano S, Croce O, Sadouni N, Győrffy B, Collet R, Renault VM, Rey-Millet M, Leonetti C, Zizza P, Allain F, Ghiringhelli F, Soubeiran N, Shkreli M, Vivier E, Biroccio A, Gilson E.

    EMBO J. 2019 Jun 3;38(11). pii: e100012. doi: 10.15252/embj.2018100012. Epub 2019 Apr 18.

    PMID: 31000523

  • Inhibiting TRF1 upstream signaling pathways to target telomeres in cancer cells.

    Cherfils-Vicini J, Gilson E.

    EMBO Mol Med. 2019 Jul;11(7):e10845. doi: 10.15252/emmm.201910845. Epub 2019 Jun 13. PMID: 31273935

  • Analysis of DNA-Protein Complexes by Atomic Force Microscopy Imaging: The Case of TRF2-Telomeric DNA Wrapping

    Pisano S, Gilson E.

    Methods Mol Biol. 2019;1886:75-97. doi: 10.1007/978-1-4939-8894-5_5.

    PMID: 30374863


  • Genome-wide Control of Heterochromatin Replication by the Telomere Capping Protein TRF2 Mol Cell. 2018 May 3;70(3):449-461.e5. doi: 10.1016

    Mendez-Bermudez A, Lototska L, Bauwens S, Giraud-Panis MJ, Croce O, Jamet K, Irizar A, Mowinckel M, Koundrioukoff S, Nottet N, Almouzni G, Teulade-Fichou MP, Schertzer M, Perderiset M, Londoño-Vallejo A, Debatisse M, Gilson E, Ye J.

    Mol Cell. 2018 May 3;70(3):449-461.e5. doi: 10.1016

    PMID: 29727617


  • TRFH domain: at the root of telomere protein evolution?

    Panis MJ, Ye J, Gilson E.

    Cell Res. 2018 Jan;28(1):7-8

    PMID: 29192673



  • Dynamics under the Telomeric Bridge

    Pisano S, Gilson E, Giraud-Panis MJ.

    Mol Cell. 2017 Nov 16;68(4):643-644

    PMID: 29149592

  • The differential spatiotemporal expression pattern of shelterin genes throughout lifespan

    Wagner K, Ying Y, Leong W, Jiang J, Hu X, Chen Y, Michiels JF, Lu Y, Gilson E*, Wagner N, Ye J

    Aging (Albany NY). 2017 Apr;9(4):1219-1232. doi: 10.18632/aging.101223

    PMID: 28437249


  • Test anxiety and telomere length: Academic stress in adolescents may not cause rapid telomere erosion

    Test anxiety and telomere length: Academic stress in adolescents may not cause rapid telomere erosion.

    Oncotarget. 2017 Feb 14;8(7):10836-10844

    PMID: 28122333

  • SIRT6 interacts with TRF2 and promotes its degradation in response to DNA damage

    Rizzo A, Iachettini S, Salvati E, Zizza P, Maresca C, D’Angelo C, Benarroch-Popivker D, Capolupo A, Del Gaudio F, Cosconati S, Di Maro S, Merlino F, Novellino E, Amoreo CA, Mottolese M, Sperduti I, Gilson E, Biroccio A.

    Nucleic Acids Res. 2017 Feb 28 ;45(4) :1820-1834

    PMID: 27923994


  • Nitric Oxide Synthase 2 Improves Proliferation and Glycolysis of Peripheral γδ T Cells

    Douguet L, Cherfils-Vicini J, Bod L, Lengagne R, Gilson E, Prévost-Blondel A.

    PLoS One. 2016 Nov 3;11(11):e0165639. doi: 10.1371/journal.pone.0165639. eCollection 2016

    PMID: 27812136


  • ERK1/2/MAPK pathway-dependent regulation of the telomeric factor TRF2

    Picco V, Coste I, Giraud-Panis MJ, Renno T, Gilson E, Pagès G.

    Oncotarget. 2016 Jul 19;7(29):46615-46627. doi: 10.18632/oncotarget.10316

    PMID: 27366950


  • High expression of TRF2, SOX10, and CD10 in circulating tumor microemboli detected in metastatic melanoma patients. A potential impact for the assessment of disease aggressiveness

    Long E, Ilie M, Bence C, Butori C, Selva E, Lalvée S, Bonnetaud C, Poissonnet G, Lacour JP, Bahadoran P, Brest P, Gilson E, Ballotti R, Hofman V, Hofman P.

    Cancer Med. 2016 Jun;5(6):1022-30. doi: 10.1002/cam4.661

    PMID: 26945789


  • Understanding why we age and how: Evolutionary biology meets different model organisms and multi-level omics: Meeting report on "Comparative Biology of Aging," Roscoff, October 12-16, 2015

    Gilson E, Bosch TC

    Bioessays. 2016 Jun;38(6):494-7

    PMID: 27119822

  • Defective DNA single-strand break repair is responsible for senescence and neoplastic escape of epithelial cells

    Nassour J, Martien S, Martin N, Deruy E, Tomellini E, Malaquin N, Bouali F, Sabatier L, Wernert N, Pinte S, Gilson E, Pourtier A, Pluquet O, Abbadie C.

    Nat C ommun., 2016, Jan 29;7:10399

    PMID: 26822533


  • TRF2-Mediated Control of Telomere DNA Topology as a Mechanism for Chromosome-End Protection.

    Benarroch-Popivker D, Pisano S, Mendez-Bermudez A, Lototska L, Kaur P, Bauwens S, Djerbi N, Latrick CM, Fraisier V, Pei B, Gay A, Jaune E, Foucher K, Cherfils-Vicini J, Aeby E, Miron S, Londoño-Vallejo A, Ye J, Le Du MH, Wang H, Gilson E,* Giraud-Panis MJ.

    Mol Cell. 2016 Jan 21;61(2):274-86

    PMID: 26774283


  • A higher-order entity formed by the flexible assembly of RAP1 with TRF2.

     Gaullier G, Miron S, Pisano S, Buisson R, Le Bihan YV, Tellier-Lebègue C, Messaoud W, Roblin P, Guimarães BG, Thai R, Giraud-Panis MJ, Gilson E, Le Du MH.

    Nucleic Acids Res., 2016, Jan 8.pii:gkv1531

    PMID: 26748096


  • Differential senescence capacities in meibomian gland carcinoma and basal cell carcinoma.

    Zhang L, Huang X, Zhu X, Ge S, Gilson E, Jia R, Ye J, Fan X.

    Int J Cancer., 2016, Mar15 ;138(6) :144252

    PMID: 26437300

  • Intragenic G-quadruplex structure formed in the human CD133 and its biological and translational relevance

    Zizza P, Cingolani C, Artuso S, Salvati E, Rizzo A, D'Angelo C, Porru M, Pagano B, Amato J, Randazzo A, Novellino E, Stoppacciaro A, Gilson E, Stassi G, Leonetti C, Biroccio A.

    Nucleic Acids Res., 2015, Oct27.pii: gkv1122

    PMID: 26511095

  • The topoisomerase II catalytic inhibitor ICRF-193 preferentially targets telomeres that are capped by TRF2.

    Chen L, Zhu X, Zou Y, Xing J, Gilson E, Lu Y, Ye J

    Am. J. Physiol. Cell. Physiol., 2015, Mar1 ;308(5) :C372-7

    PMID: 25518961


  • TRF2 acts as a transcriptional regulator in tumor angiogenesis.

    Maï ME, Wagner KD, Michiels JF, Gilson E,* Wagner N.

    Mol Cell Oncol. 2015 Jan 23;2(3):e988508

    PMID: 27308469

  • Telomere length is a prognostic biomarker in elderly advanced ovarian cancer patients: a multicenter GINECO study

    Falandry C, Horard B, Bruyas A, Legouffe E, Cretin J, Meunier J, Alexandre J, Delecroix V, Fabbro M, Certain MN, Maraval-Gaget R, Pujade-Lauraine E, Gilson E, Freyer G

    Aging (Albany NY), 2015, Dec;7(12):1066-76

    PMID: 26638179

  • TRF1 and TRF2 binding to telomeres is modulated by nucleosomal organization.

    Galati A, Micheli E, Alicata C, Ingegnere T, Cicconi A, Pusch MC, Giraud-Panis MJ, Gilson E, Cacchione S.

    Nucleic Acids Res., 2015, Jul13;43(12):5824-37

    PMID: 25999344

  • A basal level of DNA damage and telomere deprotection increases the sensitivity of cancer cells to G-quadruplex interactive compounds.

    Salvati E, Rizzo A, Iachettini S, Zizza P, Cingolani C, D’Angelo C, Porru M, Mondello C, Aiello A, Farsetti A, Gilson E, Leonetti C, Biroccio A.

    Nucleic Acids Res., 2015, Feb18 ;43(3) :1759-69

    PMID: 25618850

  • A novel pathway links telomeres to NK-cell activity: Implications for immunotherapy.

    Cherfils-Vicini J, Zizza P, Gilson E, Biroccio A.

    Oncoimmunology, 2014, Jan 1;3(1):e27358

    PMID: 24701373

  • The Wilms' tumour suppressor Wt1 is a major regulator of tumour angiogenesis and progression.

    Wagner KD, Cherfils-Vicini J, Hosen N, Hohenstein P, Gilson E, Hastie ND, Michiels JF, Wagner N

    Nat Commun., 2014, Dec16;5:5852

    PMID: 25510679

  • The basic N-terminal domain of TRF2 limits recombination endonuclease action at human telomeres.

    Saint-Léger A, Koelblen M, Civitelli L, Bah A, Djerbi N, Giraud-Panis MJ, Londoño-Vallejo A, Ascenzioni F, Gilson E.

    Cell Cycle., 2014, Jun 26;13(15) 2469-74

    PMID: 25483196

  • The Telomeric Protein TRF2 Regulates Angiogenesis by Binding and Activating the PDGFRβ Promoter.

    El Maï M, Wagner KD, Michiels JF, Ambrosetti D, Borderie A, Destree S, Renault V, Djerbi N, Giraud-Panis MJ, Gilson E*, Wagner N.

    Cell Rep., 2014, Nov6;9(3):1047-60

    PMID: 25437559

  • Length-dependent processing of telomeres in the absence of telomerase.

    Fallet E, Jolivet P, Soudet J, Lisby M, Gilson E, Teixeira MT.

    Nucleic Acids Res., 2014, Apr;42(6):3648-65

    PMID: 24393774

  • Transcriptional outcome of telomere signalling.

    Ye J, Renault VM, Jamet K, Gilson E.

    Nat. Rev. Genet., 2014, Jul;15(7):491-503

    PMID: 24913665

  • Evidence for G-quadruplex in the promoter of vegfr-2 and its targeting to inhibit tumor angiogenesis.

    Salvati E, Zizza P, Rizzo A, Iachettini S, Cingolani C, D'Angelo C, Porru M, Randazzo A, Pagano B, Novellino E, Pisanu ME, Stoppacciaro A, Spinella F, Bagnato A, Gilson E, Leonetti C, Biroccio A.

    Nucleic Acids Res., 2014, Mar;42(5):2945-57

    PMID: 24335081

  • The metabolic checkpoint kinase mTOR is essential for IL-15 signaling during the development and activation of NK cells.

    Marçais A, Cherfils-Vicini J, Viant C, Degouve S, Viel S, Fenis A, Rabilloud J, Mayol K, Tavares A, Bienvenu J, Gangloff YG, Gilson E, Vivier E, Walzer T.

    Nat. Immunol., 2014, Aug;15(8):749-57

    PMID: 24973821

  • Biology of Cancer and Aging: A Complex Association With Cellular Senescence.

    Falandry C, Bonnefoy M, Freyer G, Gilson E.

    Clin. Oncol., 2014, Aug20;32(24):2604-10

    PMID: 25071126

  • Shading the TRF2 recruiting function: a new horizon in drug development.

    Di Maro S, Zizza P, Salvati E, De Luca V, Capasso C, Fotticchia I, Pagano B, Marinelli L, Gilson E, Novellino E, Cosconati S, Biroccio A.

    J Am Chem Soc. 2014 Dec 3;136(48):16708-11

    PMID: 25393214

  • TRF2 inhibits a cell-extrinsic pathway through which natural killer cells eliminate cancer cells.

    Biroccio A, Cherfils-Vicini J, Augereau A, Pinte S, Bauwens S, Ye J, Simonet T, Horard B, Jamet K, Cervera L, Mendez-Bermudez A, Poncet D, Grataroli R, de Rodenbeeke CT, Salvati E, Rizzo A, Zizza P, Ricoul M, Cognet C, Kuilman T, Duret H, Lépinasse F, Marvel J, Verhoeyen E, Cosset FL, Peeper D, Smyth MJ, Londoño-Vallejo A, Sabatier L, Picco V, Pages G, Scoazec JY, Stoppacciaro A, Leonetti C, Vivier E, Gilson E

    Nat Cell Biol. 2013 Jul;15(7):818-28

    PMID: 23792691

  • Are aging biomarkers clinically relevant in oncogeriatrics?

    Falandry C, Gilson E, Rudolph KL.

    Crit Rev Oncol Hematol. 2013 Mar;85(3):257-65

    PMID: 22948097

  • Effect of Rap1 binding on DNA distortion and potassium permanganate hypersensitivity.

    Le Bihan YV, Matot B, Pietrement O, Giraud-Panis MJ, Gasparini S, Le Cam E, Gilson E, Sclavi B, Miron S, Le Du MH.

    Acta Crystallogr D Biol Crystallogr. 2013 Mar;69(Pt 3):409-19

    PMID: 23519416


  • One identity or more for telomeres?

    Giraud-Panis MJ, Pisano S, Benarroch-Popivker D, Pei B, Le Du MH, Gilson E (*).

    Front Oncol. 2013;3:48

    PMID: 23509004

  • Super-telomeres in transformed human fibroblasts

    Chiodi I, Belgiovine C, Zongaro S, Ricotti R, Horard B, Lossani A, Focher F, Gilson E, Giulotto E, Mondello C.

    Biochim Biophys Acta. 2013 Aug;1833(8):1885-93

    PMID: 23570868


  • Acacetin and chrysin, two polyphenolic compounds, alleviate telomeric position effect in human cells

     Boussouar A, Barette C, Nadon R, Saint-Léger A, Broucqsault N, Ottaviani A, Firozhoussen A, Lu Y, Lafanechère L, Gilson E. Magdinier F , Ye J.

    Mol Ther Nucleic Acids. 2013 Aug 20;2:e116

    PMID: 23962900

  • Telomeric impact of conventional chemotherapy


    Lu Y, Leong W, Guérin O, Gilson E, Ye J.

    Front Med. 2013 Dec;7(4):411-7

    PMID: 24155095

  • Telomere protection and TRF2 expression are enhanced by the the canonical Wnt signalling pathway.

    Diala I, Wagner N, Magdinier F, Shkreli M, Sirakov M, Bauwens S, Schluth-Bolard C, Simonet T, Renault VM, Ye J, Djerbi A, Pineau P, Choi J, Artandi S, Dejean A, Plateroti M, Gilson E.

    EMBO Rep. 2013 Apr;14(4):356-63

    PMID: 23429341

  • A snapshot of histone modifications within transposable elements in Drosophila wild type strains.

     Rebollo R, Horard B, Begeot F, Delattre M, Gilson E, Vieira C.

    PLoS One. 2012;7(9):e44253

    PMID: 22962605


  • RPA facilitates telomerase activity at chromosome ends in budding and fission yeasts.

    Luciano P, Coulon S, Faure V, Corda Y, Bos J, Brill SJ, Gilson E, Simon MN, Géli V.  (2012)

    EMBO J. 2012 Apr 18;31(8):2034-46

    PMID: 22354040

  • TRF2 controls telomeric nucleosome organization in a cell cycle phase-dependent manner

    Galati A, Magdinier F, Colasanti V, Bauwens S, Pinte S, Ricordy R, Giraud-Panis MJ, Pusch MC, Savino M, Cacchione S, Gilson E. (*).

    PLoS One. 2012;7(4):e34386

    PMID: 22536324

  • Comprehensive DNA methylation profiling of human repetitive DNA elements using an MeDIP-on-RepArray assay

    Gilson E, Horard B.

    Methods Mol Biol. 2012;859:267-91.

    PMID: 22367878

  • RPA facilitates telomerase activity at chromosome ends in budding and fission yeasts

    Luciano P, Coulon S, Faure V, Corda Y, Bos J, Brill SJ, Gilson E, Simon MN, Géli V

    EMBO J. 2012 Apr 18;31(8):2034-46.

    PMID: 22354040

  • The N-terminal domains of TRF1 and TRF2 regulate their ability to condense telomeric DNA.

    Poulet A, Pisano S, Faivre-Moskalenko C, Pei B, Tauran Y, Haftek-Terreau Z, Brunet F, Le Bihan YV, Ledu MH, Montel F, Hugo N, Amiard S, Argoul F, Chaboud A, Gilson E(*), Giraud-Panis MJ.

    Nucleic Acids Res. 2012 Mar;40(6):2566-76.

    PMID: 22139926


  • HTLV-1 positive and negative T cells cloned from infected individuals display telomerase and telomere genes deregulation that predominate in activated but untransformed CD4+ T cells.

    Zane L, Sibon D, Capraro V, Galia P, Karam M, Delfau-Larue MH, Gilson E, Gessain A, Gout O, Hermine O, Mortreux F, Wattel E.

    Int J Cancer. 2012 Aug 15;131(4):821-33.

    PMID: 21717459

Les équipes de recherche