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External Seminar : « A garden of forking paths: branching, switching and reversal in meiotic recombination » – Michael Lichten

Abstract: Meiotic recombination involves repair of double strand DNA breaks by homologous recombination to form crossovers and noncrossovers. Current models suggest that different mechanisms form these two products: noncrossovers by synthesis-dependent strand annealing; COs by double Holliday junction formation and resolution. In testing these predictions, we found evidence for remarkable dynamism during meiotic DSB repair. […]

Internal Seminar : « The role of p16High state in oocytes in intergenerational programming of adult phenotypes. » Alessandra PIERANTONI (Equipe Dmitry BULAVIN)

Faculté de Médecine - Amphitheâtre 1

Abstract: Cellular senescence is conventionally defined as a state of permanent cell cycle arrest in response to multiple stress factors such as DNA damage but also aging. Excessive accumulation of senescent cells can negatively impact different tissues, creating a proinflammatory environment leading to development of various age-related diseases. This project is focus on the analysis […]

Internal Seminar : « Stress signals and hematopoietic stem cell aging » by Giang TO VU (Equipe Eirini TROMPOUKI)

Faculté de Médecine - Amphitheâtre 1

Hematopoietic stem cells (HSCs) are pluripotent cells that have capacity to replenish all blood cells. HSCs stay quiescent| in the bone marrow niche, until they get triggered to differentiate, which is also happening during aging. However, whether aging is a collection of moments of stress signals that make HSCs exit quiescence is not known. Here, […]

6th LABEX SIGNALIFE Meeting

The Labex SIGNALIFE Scientific Council is happy to announce to all scientists from Nice and the Côte d’Azur region the 6th SIGNALIFE meeting on Cell Signaling that will occur on 12-13 November 2024 at the Saint Paul Hôtel in Nice.

External Seminar: « On the multiple roads to cell fate decision: Integrating transcription factors into RNA-regulatory networks  » – Julie CARNESECCHI

Gaël CRISTOFARI invites Julie CARNESECCHI  from the Institut de Génétique Moléculaire de Montpellier Location: Faculté de Médecine, Amphithéâtre 4 Abstract: While the current view states that Transcription Factors (TFs) act on DNA regulatory elements to deploy precise gene programs, an emerging concept proposes that TFs also bind RNA and regulate splicing to promote molecular and […]

Thesis defense: « Cellular factors and genomic features influencing transcription elongation » – Victor BILLON

Faculté de Médecine - Amphitheâtre 1

Thesis director: Gaël CRISTOFARI Abstract : A major part of gene introns contains cryptic splicing, termination signals, and abundant DNA and RNA protein-binding sites. These sequences are often found in mobile DNA units known as transposable elements embedded in long genes. These sequences could interfere with the transcription elongation of the genes in which they […]

External Seminar: « Role of endogenous retrovirus in response to checkpoint inhibitors » – François GHIRINGHELLI

Paul HOFMAN invites François GHIRINGHELLI (Centre de Lutte contre le Cancer Georges François Leclerc, Dijon) to IHU RESPIRera seminar. Location: Hôpital Pasteur 1 Pavillon I. Espace Universitaire Médecine Personalisée “Master Class Paradise” Abstract: He is Professor of Medical Oncology at the University of Burgundy, Director of the UMR INSERM 1231, and head of the team […]