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External Seminar : « A garden of forking paths: branching, switching and reversal in meiotic recombination » – Michael Lichten

Abstract: Meiotic recombination involves repair of double strand DNA breaks by homologous recombination to form crossovers and noncrossovers. Current models suggest that different mechanisms form these two products: noncrossovers by synthesis-dependent strand annealing; COs by double Holliday junction formation and resolution. In testing these predictions, we found evidence for remarkable dynamism during meiotic DSB repair. […]

Internal Seminar : « The role of p16High state in oocytes in intergenerational programming of adult phenotypes. » Alessandra PIERANTONI (Equipe Dmitry BULAVIN)

Faculté de Médecine - Amphitheâtre 4

Abstract: Cellular senescence is conventionally defined as a state of permanent cell cycle arrest in response to multiple stress factors such as DNA damage but also aging. Excessive accumulation of senescent cells can negatively impact different tissues, creating a proinflammatory environment leading to development of various age-related diseases. This project is focus on the analysis […]

Internal Seminar : « Stress signals and hematopoietic stem cell aging » by Giang TO VU (Equipe Eirini TROMPOUKI)

Faculté de Médecine - Amphitheâtre 4

Hematopoietic stem cells (HSCs) are pluripotent cells that have capacity to replenish all blood cells. HSCs stay quiescent| in the bone marrow niche, until they get triggered to differentiate, which is also happening during aging. However, whether aging is a collection of moments of stress signals that make HSCs exit quiescence is not known. Here, […]