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Équipe Emmanuel VAN OBBERGHEN

Présentation

Equipe de Recherche Fondamentale  « Diabète et Vieillissement »


Pr Emmanuel VAN OBBERGHEN, PU-PH CE Emérite, Chef d'Equipe



Projet de Recherche


Diabetes and cardiovascular diseases afflict an increasing percentage of the ageing population. A tight link exists between these pathologies as diabetes predisposes to cardiac failure and conversely cardiovascular complications are the chief cause of increased mortality in diabetes. Both environmental/lifestyle factors and genetic factors participate in the defects of type 2 diabetes (T2D), which are insufficient insulin secretion and insulin resistance. An emerging paradigm is that the risk of chronic diseases in adult life is accounted for, at least in part, environmental influences, particularly those occurring in utero. Supporting this is the increased T2D risk in offspring of overfed mothers or exposed to deleterious uterine conditions. Our hypothesis is that under deleterious in utero conditions, the altered control exerted by miRNAs on gene regulation increases the risk of insulin resistance and T2D in adult life. We study offsprings of rat dams exposed during pregnancy to an inappropriate diet or to a deficient uterine environment, leading to increased insulin resistance and T2D risk, and identify miRNAs with modified expression in the liver and pancreas of the offspring. We also study the impact of the deleterious maternal environment on cardiac development.

The age-related increase in T2D involves beta cell failure due to insulin resistance. Therefore, we investigate whether age-related alterations in the dialogue between beta cells and endothelial cells participate in pancreatic insufficiency. Finally, as both ageing and diabetes have deleterious effects on kidney function we investigate the potential role of insulin resistance related factors on the kidney.

We believe that our multipronged approach using powerful cutting edge technologies will allow us to develop our proposal successfully, and significantly advance the understanding of the mechanisms leading to increased diabetes incidence during ageing. Our project will have important medical implications by fostering the development of prevention strategies for T2D and its cardiovascular complications, and may in the future harness the epidemic growth of the diseases. Hence the impact of our endeavour is likely to lead to health promotion.


Equipe de Recherche

Equipe de Recherche



VAN OBBERGHEN Emmanuel, PU-PH CE Emérite, Chef d'Equipe
Tel : +33 (04) 93 37 77 85, Mail : This e-mail address is being protected from spambots. You need JavaScript enabled to view it

CANIVET Bertrand, PU-PH1
Tel : +33 (04) 93 37 xx xx, Mail : This e-mail address is being protected from spambots. You need JavaScript enabled to view it

CHINETTI Giulia, PU-PH1

Tel : +33 (04) 93 37 xx xx, Mail : This e-mail address is being protected from spambots. You need JavaScript enabled to view it


DUMORTIER Olivier, Post-doc
Tel : +33 (04) 93 37 xx xx, Mail : olivier.dumortier@unice.fr

ESNAULT Vincent, PU-PH1
Tel : +33 (04) 93 37 xx xx, Mail : esnault.v@chu-nice.fr

FABRIS Gaia, PhD Student

Tel : +33 (04) 93 37 xx xx, Mail : This e-mail address is being protected from spambots. You need JavaScript enabled to view it


FAVRE Guillaume, PH (Contrat interface INSERM)
Tel : +33 (04) 93 37 xx xx, Mail : favre.g@chu-nice.fr

GAUTIER Nadine, IEHC INSERM (80 %)
Tel : +33 (04) 93 37 xx xx, Mail : nadine.gautier@unice.fr

HINAULT Charlotte, MCU-PH
Tel : +33 (04) 93 37 xx xx, Mail : hinault.c@chu-nice.fr

ICHAI Carole, PU-PH1
Tel : +33 (04) 93 37 xx xx, Mail : ichai.c@chu-nice.fr

LAREYRE Fabien, PhD Student

Tel : +33 (04) 93 37 xx xx, Mail : This e-mail address is being protected from spambots. You need JavaScript enabled to view it


LEBRUN Patricia, MCU UNS
Tel : +33 (04) 93 37 xx xx, Mail : patricia.lebrun@unice.fr

MANFRONI Georges, TCN INSERM (50 %)
Tel : +33 (04) 93 37 xx xx, Mail : georges.manfroni@unice.fr

NAIMI Mourad, MCU-PH1
Tel : +33 (04) 93 37 xx xx, Mail : mourad.naimi@unice.fr

ORBAN Jean-Christophe, PH
Tel : +33 (04) 93 37 xx xx, Mail : orban.j-c@chu-nice.fr

PANAIA-FERRARI Patricia, PH

Tel : +33 (04) 93 37 xx xx, Mail : This e-mail address is being protected from spambots. You need JavaScript enabled to view it


RAFFORT Juliette, PhD Student

Tel : +33 (04) 93 37 xx xx, Mail : This e-mail address is being protected from spambots. You need JavaScript enabled to view it


ROGER Estelle, PhD Student

Tel : +33 (04) 93 37 xx xx, Mail : This e-mail address is being protected from spambots. You need JavaScript enabled to view it


SENLIS Jean-Eric, AHU
Tel : +33 (04) 93 37 xx xx, Mail : senlis.j-e@chu-nice.fr

(Fev 2016)

Distinctions

Mai 2016 :

Le Pr Emmanuel Van Obberghen reçoit la médaille Paul Langerhans,

la plus haute distinction honorifique octroyée par la Société Allemande du Diabète.


  


Publications

Publications


2015


Raffort J, Hinault C, Dumortier O, Van Obberghen E.

Circulating microRNAs and diabetes: potential applications in medical practice.

Diabetologia, 2015, Sep;58(9):1978-92.


Favre GA, Esnault VL, Van Obberghen E.

Modulation of glucose metabolism by the renin-angiotensin-aldosterone system.

Am J Physiol Endocrinol Metab., 2015, Mar 15;308(6):E435-49.


2014


Favre GA, Lebrun P, Lopez P, Butori C, Hofman P, Esnault VL, Van Obberghen E.

Constitutive activation of the renin-angiotensin system reduces visceral fat and improves

glucose tolerance in mice.

J Renin Angiotensin Aldosterone Syst., 2014, Dec;15(4):396-409.


Orban JC, Maizière EM, Ghaddab A, Van Obberghen E, Ichai C.

Incidence and characteristics of acute kidney injury in severe diabetic ketoacidosis.

PLoS One, 2014, Oct 22;9(10):e110925.


Dumortier O, Hinault C, Gautier N, Patouraux S, Casamento V, Van Obberghen E.

Maternal protein restriction leads to pancreatic failure in offspring: role of misexpressed

microRNA-375.

Diabetes. 2014 Oct;63(10):3416-27.


Favre GA, Touzot M, Fremeaux-Bacchi V, Hyvernat H, Gueffet JP, Rohrlich PS, Queyrel V,

Esnault V, Fakhouri F.

Malignancy and thrombotic microangiopathy or atypical haemolytic and uraemic syndrome ?

British J Hematol, 2014, John Wiley & Sons Ltd., doi :10.1111/bjh-12907.


Bonesso L, Piraud M, Caruba C, Van Obberghen E, Mengual R, Hinault C.
Fast urinary screening of oligosaccharidoses by MALDI-TOF/TOF mass
spectrometry.
Orphanet J Rare Dis., 2014, Feb 6;9(1):19.

2013

Hinault C, Dumortier O, Van Obberghen E.,
MicroRNA and diabetes : tiny things causing huge effects.
Med Sci (Paris). 2013, 29(8-9):785-90.

Dumortier O, Hinault C, Van Obberghen E.,
MicroRNAs and Metabolism Crosstalk in Energy Homeostasis.
Cell Metab. 2013 Sep 3;18(3):312-24.

2012

Dumortier O, Van Obberghen E
MicroRNAs in pancreas development.
Diabetes Obes Metab, 2012, 14 Suppl 3:22-28.

2011

Fiory F, Lombardi A, Miele C, Giudicelli J, Beguinot F, Van Obberghen E
Methylglyoxal impairs insulin signalling and insulin action on glucose-induced insulin secretion
in the pancreatic beta cell line INS-1E.
Diabetologia, 2011, 54:2941-2952.

Arous C, Naimi M, Van Obberghen E
Oleate-mediated activation of phospholipase D and mammalian target of rapamycin (mTOR)
regulates proliferation and rapamycin sensitivity of hepatocarcinoma cells.
Diabetologia, 2011, 54:954-964.

2010

Naimi M, Arous C, Van Obberghen E
Energetic cell sensors: a key to metabolic homeostasis.
Trends Endocrinol Metab, 2010, 21:75-82.

Lebrun P, Cognard E, Gontard P, Bellon-Paul R, Filloux C, Berthault MF, Magnan C,
Ruberte J, Luppo M, Pujol A, Pachera N, Herchuelz A, Bosch F, Van Obberghen E
The suppressor of cytokine signalling 2 (SOCS2) is a key repressor of insulin secretion.
Diabetologia, 2010, 53:1935-1946.

2009

Lebrun P, Cognard E, Bellon-Paul R, Gontard P, Filloux C, Jehl-Pietri C, Grimaldi P,
Samson M, Penicaud L, Ruberte J, Ferre T, Pujol A, Bosch F, Van Obberghen E
Constitutive expression of suppressor of cytokine signalling-3 in skeletal muscle
leads to reduced mobility and overweight in mice.
Diabetologia, 2009, 52:2201-2212.

Hasseine LK, Hinault C, Lebrun P, Gautier N, Paul-Bellon R, Van Obberghen E
miR-139 impacts FoxO1 action by decreasing FoxO1 protein in mouse hepatocytes.
Biochem Biophys Res Commun., 2009, 390:1278-1282.

Baroukh NN, Van Obberghen E
Function of microRNA-375 and microRNA-124a in pancreas and brain.
Febs J., 2009, 276:6509-6521.

2008

Segalen C, Longnus SL, Baetz D, Counillon L, Van Obberghen E
5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside reduces glucose uptake
via the inhibition of Na+/H+ exchanger 1 in isolated rat ventricular cardiomyocytes.
Endocrinology, 2008, 149:1490-1498.

El Ouaamari A, Baroukh N, Martens GA, Lebrun P, Pipeleers D, van Obberghen E
miR-375 targets 3'-phosphoinositide-dependent protein kinase-1 and regulates
glucose-induced biological responses in pancreatic beta-cells.
Diabetes, 2008, 57:2708-2717.

Demozay D, Mas JC, Rocchi S, Van Obberghen E
FALDH reverses the deleterious action of oxidative stress induced by lipid peroxidation
product 4-hydroxynonenal on insulin signaling in 3T3-L1 adipocytes.
Diabetes, 2008, 57:1216-1226.

2007

Naimi M, Gautier N, Chaussade C, Valverde AM, Accili D, Van Obberghen E
Nuclear forkhead box O1 controls and integrates key signaling pathways in hepatocytes.
Endocrinology, 2007, 148:2424-2434.

Baroukh N, Ravier MA, Loder MK, Hill EV, Bounacer A, Scharfmann R, Rutter GA,
Van Obberghen E
MicroRNA-124a regulates Foxa2 expression and intracellular signaling in pancreatic
beta-cell lines.
J Biol Chem., 2007, 282:19575-19588.

2006

Riboulet-Chavey A, Pierron A, Durand I, Murdaca J, Giudicelli J, Van Obberghen E
Methylglyoxal impairs the insulin signaling pathways independently of the formation
of intracellular reactive oxygen species.
Diabetes, 2006, 55:1289-1299.

Hinault C, Mothe-Satney I, Gautier N, Van Obberghen E
Amino acids require glucose to enhance, through phosphoinositide-dependent
protein kinase 1, the insulin-activated protein kinase B cascade in insulin-resistant
rat adipocytes.
Diabetologia, 2006, 49:1017-1026.


(Feb 2016)


Financements

Financements