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Some Relevant Publications

Benarroch-Popivker D, Pisano S, Mendez-Bermudez A, Lototska L, Kaur P, Bauwens S, Djerbi N, Latrick CM, Fraisier V, Pei B, Gay A, Jaune E, Foucher K, Cherfils-Vicini J, Aeby E, Miron S, Londoño-Vallejo A, Ye J, Le Du MH, Wang H, Gilson E, Giraud-Panis MJ.

TRF2-Mediated Control of Telomere DNA Topology as a Mechanism for Chromosome-End Protection.

Mol Cell. 2016, Jan 21;61(2):274-86.


Brichkina A, Nguyen NT, Baskar R, Wee S, Gunaratne J, Robinson RC, Bulavin DV.

Proline isomerisation as a novel regulatory mechanism for p38MAPK activation and functions.

Cell Death Differ., 2016, Oct;23(10):1592-601.


C Philippe, DB Vargas-Landin, AJ Doucet, D Van Essen, J Vera-Otarola, M Kuciak, A Corbin, P Nigumann, G Cristofari

L'activation des instances de rétrotransposon L1 individuels est limitée à la cellule de type loci permissive dépendante.

eLife, Mars 2016; 10,7554 / eLife.13926


Hofman P, Cherfils-Vicini J, Bazin M, Ilie M, Juhel T, Hébuterne X, Gilson E, Schmid-Alliana A,

Boyer P, Adriouch S, Vouret-Craviari V.

Genetic and pharmacological inactivation of the purinergic P2RX7 receptor dampens inflammation

but increases tumor incidence in a mouse model of colitis-associated cancer.

Cancer Res., 2015, 75,:835-45.


Mimouna S, Bazin M, Mograbi B, Darfeuille-Michaud A, Brest P, Hofman P, Vouret-Craviari V.

HIF1A regulates xenophagic degradation of Adherent and Invasive Escherichia coli (AIEC).

Autophagy, 2014, 10:2333-2345.


Estrach S, Lee SA, Boulter E, Pisano S, Errante A, Tissot FS, Cailleteau L, Pons C,

Ginsberg MH, Féral CC.

CD98hc (SLC3A2) loss protects against ras-driven tumorigenesis by modulating

integrin-mediated mechanotransduction.

Cancer Research, 2014, Dec1;74(23):6878-89.


Albrengues J, Bourget I, Pons C, Butet V, Hofman P, Tartare-Deckert S, Féral CC,

Meneguzzi G, Gaggioli C.

LIF mediates proinvasive activation of stromal fibroblasts in cancer.

Cell. Rep., 2014, Jun 12;7(5):1664-78.


Boulter E, Estrach S, Errante A, Pons C, Cailleteau L, Tissot F, Meneguzzi G, Féral CC.

CD98hc (SLC3A2) regulation of skin homeostasis wanes with age.

J Exp Med., 2013, Jan. 210:173-190.


Filipponi D, Muller J, Emelyanov A, Bulavin DV.

Wip1 controls global heterochromatin silencing via ATM/BRCA1-dependent DNA methylation.

Cancer Cell, 2013, Oct 14;24(4):528-41.


Zhu Y, Huang YF, Kek C, Bulavin DV.

Apoptosis differently affects lineage tracing of Lgr5 and Bmi1 intestinal stem cell populations.

Cell. Stem Cell., 2013, Mar 7;12(3):298-303.


Röttinger E, Dahlin P, Martindale QM

A Framework to establish a Cnidarian Gene Regulatory Network for “Endomesoderm” Specification: The inputs of ß-catenin/TCF signaling.

PLOS Genetics, 2012, 8 (12), e1003164.


Röttinger E, Martindale QM.

Ventralization of an indirect developing hemichordate by NiCl2 suggest a conserved

mechanism in dorso-ventral (D/V) patterning in Ambulacraria (Hemichordates and Echinoderms).

Developmental Biology, 2011, 354 (1), 173-190.


Chaussenot A, Le Ber I, Ait-El-Mkadem S, Camuzat A, de Septenville A, Bannwarth S, Genin EC, Serre V, Augé G, The French research network on FTD and FTD-ALS, Brice A, Pouget J, Paquis-Flucklinger V

Screening of CHCHD10 in a French cohort confirms the involvement of this gene in FTD-ALS.

Neurobiology of Aging, 2014, Jul 24. pii: S0197-4580(14)00491-6.

Bannwarth S, Ait-El-Mkadem S, Chaussenot A, Genin EC, Lacas-Gervais S, Fragaki K,  Berg-Alonso L, Kageyama Y, Serre V, Moore D, Verschueren A, Rouzier C, Le Ber I, Augé G, Cochaud C, Lespinasse F, N’Guyen K, de Septenville A, Brice A, Yu Wai Man P, Sesaki H, Pouget J, Paquis-Flucklinger V.

A mitochondrial origin for frontotemporal dementia and amyotrophic lateral sclerosis through CHCHD10 involvement.

Brain, 2014, 137: 2329-2345.


Bergstrom A, Simpson JT, Salinas B, Barre B, Parts L, Zia A, Nguyen Ba AN, Moses AM, Louis EJ, Mustonen V, Warringer J, Durbin R, Liti G.

New sequencing tools give up close look at yeast evolution.

Mol. Biol. and Evolution, 2014, DOI:10, 1093/molbev/msu037.


Papaconstantinou J, Wang CZ, Zhang M, Yang S, Deford J, Bulavin DV, Ansari NH

Attenuation of p38alpha MAPK stress response signaling delays the in vivo aging of skeletal muscle myofibers and progenitor cells.

Aging (Albany NY), 2015, Sep 7(9):718-33.


Saâda-Bouzid , Burel-Vandenbos F, Ranchère-Vince D, Birtwisle-Peyrottes I, Chetaille B, Bouvier C, Château MC, Peoc'h , Battistella M, Bazin A, Gal J, Michiels JF, Coindre JM, Pedeutour F, Bianchini L

Prognostic value of HMGA2, CDK4, and JUN amplification in well-differentiated and dedifferentiated liposarcomas.
Mod Pathol., 2015, Sep 4, sous presse.


Dadone B, Refae S, Lemarié-Delaunay C, Bianchini L, Pedeutour F.

Molecular cytogenetics of pediatric adipocytic tumors.

Cancer Genet., 2015, Oct;208(10):469-81.


Liti G

The fascinating and secret wild life of the budding yeast S. cerevisiae.

Elife, 2015, Mar 25;4.


Grépin R, Guyot M, Giuliano S, Boncompagni M, Ambrosetti D, Chamorey E,
Scoazec JY, Negrier S, Simonnet H, Pagès G.

The CXCL7/CXCR1/2 axis is a key driver in the growth of clear cell
renal cell carcinoma.

Cancer Res, 2014, Feb 1;74(3):873-83.


Griseri P, Pagès G.
Control of pro-angiogenic cytokine mRNA half-life in cancer: the role of
AU-rich elements and associated proteins.

J Interferon Cytokine Res, 2014, Apr;34(4):242-54.


Huang YF, Bulavin DV.

Oncogene-mediated regulation of p53 ISGylation and functions.
Oncotarget, 2014, Jul 11, in print.


Zhu Y, Demidov ON, Goh AM, Virshup DM, Lane DP, Bulavin DV.
Phosphatase WIP1 regulates adult neurogenesis and WNT signaling during aging.
J Clin Invest., 2014, Jun 9. pii: 73015.

Huang YF, Wee S, Gunaratne J, Lane DP, Bulavin DV.
Isg15 controls p53 stability and functions.
Cell Cycle, 2014, May 20;13(14).

Dumortier O, Hinault C, Gautier N, Patouraux S, Casamento V, Van Obberghen E.
Maternal protein restriction leads to pancreatic failure in offspring of misexpressed microRNA-375.
Diabetes, 2014, May 16 :131431.


Grépin R, Ambrosetti D, Marsaud A, Gastaud L, Amiel J, Pedeutour F, Pagès G.
The relevance of testing the efficacity of anti-angiogenesis treatments on cells derived from primary tumors :
a new method for the personalized treatment of renal cell carcinoma.
PLoS One, 2014, Mar 27;9(3):e89449.

Bonesso L, Piraud M, Caruba C, Van Obberghen E, Mengual R, Hinault C.
Fast urinary screening of oligosaccharidoses by MALDI-TOF/TOF mass spectrometry.
Orphanet J Rare Dis., 2014, Feb 6;9(1):19.

Bergström A, Simpson JT, Salinas F, Barré B, Parts L, Zia A,
Nguyen Ba AN, Moses AM, Louis EJ, Mustonen V, Warringer W,
Durbin R and Liti G.
A high-definition view of functional genetic variation from natural yeast genomes.
Molecular Biology and Evolution, 2014. In press.

Brown WR, Thomas G, Lee NC, Blythe M, Liti G, Warringer J, Loose MW.
Kinetochore assembly and heterochromatin formation occur autonomously in
Schizosaccharomyces pombe.
PNAS, 2014. In press.

Parks S, Chiche J, Pouysségur, J.,
Disrupting proton dynamics and energy metabolism for cancer therapy.
Nature Rev. Cancer, 2013, 3(9):611-23.

Lutz NW, Le Fur Y, Chiche J, Pouyssegur J, Cozzone PJ.
Quantitative in-vivo characterization of intracellular and extracellular pH
profiles in heterogeneous tumors: a novel method enabling multiparametric
pH analysis.
Cancer Res., 2013, 73 :4616-28.

Cubillos FA, Pièces L, Salinas F, Bergström A, Scovacricchi E, Zia A, Chef Illingworth,
Mustonen V, Ibstedt S, Warringer J, Louis EJ, Durbin R, Liti G.
High resolution mapping of complex traits with a four-parent advanced intercross yeast population
Genetics,  September 20, 2013,113,155515.

Hinault C, Dumortier O, Van Obberghen E.
MicroRNA and diabetes : tiny things causing huge effects.
Med Sci (Paris). 2013, 29(8-9):785-90.

Dumortier O, Hinault C, Van Obberghen E.
MicroRNAs and Metabolism Crosstalk in Energy Homeostasis.
Cell Metab. 2013 Sep 3;18(3):312-24.

Boussouar A, Barette C, Nadon R, Saint-Léger A, Broucqsault N, Ottaviani A,
Firozhoussen A, Lu Y, Lafanechère L, Gilson E, Magdinier F,
Acacetin and chrysin, two polyphenolic compounds, alleviate telomeric position effect in
human cells. 
J Mol Ther Nucleic Acids. 2013 Aug 20;2:e116.

Biroccio A, Cherfils-Vicini J, Augereau A, Pinte S, Bauwens S, Ye J, Simonet
T, Horard B, Jamet K, Cervera L, Mendez-Bermudez A, Poncet D, Grataroli R,
de Rodenbeeke CT, Salvati E, Rizzo A, Zizza P, Ricoul M, Cognet C, Kuilman
T, Duret H, Lépinasse F, Marvel J, Verhoeyen E, Cosset FL, Peeper D, Smyth
MJ, Londoño-Vallejo A, Sabatier L, Picco V, Pagès G, Scoazec JY,
Stoppacciaro A, Leonetti C, Vivier E, Gilson E.
TRF2 inhibits a cell-extrinsic pathway through which natural killer cells eliminate cancer
cells.
Nat Cell Biol. 2013 Jul;15(7):818-28.

Giraud-Panis MJ, Pisano S, Benarroch-Popivker D, Pei B, Le Du MH, Gilson E.
One identity or more for telomeres ?
Front Oncol., 2013;3:48.

Diala I, Wagner N, Magdinier F, Shkreli M, Sirakov M, Bauwens S,
Schluth-Bolard C, Simonet T, Renault VM, Ye J, Djerbi A, Pineau P, Choi J,
Artandi S, Dejean A, Plateroti M, Gilson E.
Telomere protection and TRF2 expression are enhanced by the canonical Wnt signalling pathway.
EMBO Rep., 2013 Apr;14(4):356-63.

Falandry C, Gilson E, Rudolph KL.
Are aging biomarkers clinically relevant in oncogeriatrics ?
Crit Rev Oncol Hematol., 2013 Mar;85(3):257-65.

Galati A, Magdinier F, Colasanti V, Bauwens S, Pinte S, Ricordy R,
Giraud-Panis MJ, Pusch MC, Savino M, Cacchione S, Gilson E.
TRF2 controls telomeric nucleosome organization in a cell cycle phase-dependent manner.
PLoS One., 2012;7(4):e34386.

Monot C*, Kuciak M*, Viollet S, Mir AA, Gabus C, Darlix JL, Cristofari G.
The specificity and flexibility of L1 reverse transcription priming at imperfect T-Tracts. 
PLoS Genet. 2013, In Press. (* co-first authors)

Goic B, Vodovar N, Mondotte JA, Monot C, Frangeul L, Blanc H, Gausson V, Vera-Otarola J, Cristofari G, Saleh MC.
RNA-mediated interference and reverse transcription control the persistence of RNA viruses in the insect model Drosophila. 
Nat Immunol., (2013), 14(4):396-403.

Sauerwald A, Sandin S, Cristofari G, Scheres SH, Lingner J, Rhodes D.
Structure of active dimeric human telomerase. 
Nat Struct Mol Biol., (2013), 20(4):454-60.

Giuliano S, Pagès G.
Mechanisms of resistance to anti-angiogenesis therapies.
Biochimie, 2013, Mar 15, in press

Bianchini L, Birtwisle L, Saada E, Bazin A, Long E, Roussel J-F, Michiels J-F, Forest F, Dani C, Myklebost O, Birtwisle-Peyrottes I, Pedeutour F.
Identification of PPAP2B as a novel recurrent translocation partner gene of HMGA2 in lipomas.
Genes, Chromosomes & Cancer, 2013, in press

Sanfiorenzo C, Ilie MI, Belaid A, Barlési F, Mouroux J, Marquette CH, Brest P, Hofman P.
Two Panels of Plasma MicroRNAs as Non-Invasive Biomarkers for Prediction of Recurrence in Resectable NSCLC.
PLoS One. 2013;8(1):e54596. Epub 2013 Jan 16.

Hofman V, Ilie M, Long-Mira E, Giacchero D, Butori C, Dadone B, Selva E, Tanga V, Passeron T, Poissonnet G, Emile JF, Lacour JP, Bahadoran P, Hofman P.
Usefulness of Immunocytochemistry for the Detection of the BRAF(V600E) Mutation in Circulating Tumor Cells from Metastatic Melanoma Patients.
J Invest Dermatol. 2013 Jan 10, 485.

Boulter E, Estrach S, Errante A, Pons C, Cailleteau L, Tissot F, Meneguzzi G, Féral CC.
CD98hc (SLC3A2) Regulation of Skin Homeostasis Wanes with Age.
J Exp Med., 2013, Jan 14;210(1):173-90.

Boulter E, Estrach S, Garcia-Mata R, Féral CC.
Off the beaten paths: alternative and crosstalk regulation of Rho GTPases.
FASEB J. 2012, 26(2):469-79.

Mothe-Satney I, Filloux C, Amghar H, Pons C, Bourlier V, Galitzky J, Grimaldi PA, Féral CC, Bouloumié A, Van Obberghen E, Neels JG.
Adipocytes Secrete Leukotrienes : Contribution to Obesity-Associated Inflammation and Insulin Resistance in Mice. 
Diabetes. 2012 Sep.61(9):2311-9.

Dumortier O, Van Obberghen E.
MicroRNAs in pancreas development.
Diabetes Obes Metab., 2012, 14 Suppl 3:22-28.

Layden J M., Röttinger E., Wolenski S F., Gilmore D T., Martindale Q M.
Microinjection of mRNA or morpholinos for reverse genetic analysis in the starlet sea anemone, Nematostella vectensis.
Nature Protocols (in press, 2012)

Röttinger E., Dahlin P., Martindale M. Q.
A Framework to establish a Cnidarian Gene Regulatory Network for “Endomesoderm” Specification: The inputs of ß-catenin/TCF signaling.
PLOS Genetics, 8 (12), e1003164 (2012)

Zörgö E, Gjuvsland A, Cubillos FA, Louis EJ, Liti G, Blomberg A, Omholt SW, Warringer J.
Life History Shapes Trait Heredity by Accumulation of Loss-of-Function Alleles in Yeast.
Mol Biol Evol. 2012 Jul;29(7):1781-9.

Illingworth CJ, Parts L, Schiffels S, Liti G, Mustonen V.
Quantifying selection acting on a complex trait using allele frequency time series data.
Mol Biol Evol. 2012 Apr;29(4):1187-97.

Ainouche A, Bétermier M, Chandler M, Cordaux R, Cristofari G, Deragon JM, Lesage P, Panaud O, Quesneville H, Vaury C, Vieira C, Vitte C. (2012) 
International Congress on Transposable Elements (ICTE) 2012 in Saint Malo and the sea of TE stories.
Mobile DNA. 3(1):17.

Vidale P, Magnani E, Nergadze SG, Santagostino M, Cristofari G, Smirnova A, Mondello C, Giulotto E. (2012)
The catalytic and the RNA subunits of human telomerase are required to immortalize equid primary fibroblasts.
Chromosoma. 121(5):475-88.

Shkreli M, Sarin KY, Pech MF, Papeta N, Chang W, Brockman SA, Cheung P, Lee E, Kuhnert F, Olson JL, Kuo CJ, Gharavi AG, D’Agati VD, Artandi SE.
Reversible cell cycle entry in adult kidney podocytes through regulated control of telomerase and Wnt signaling.
Nature Medicine, 2012 (Published online: 04 December 2011 | doi:10.1038/nm.2550).

Warrick, E., Garcia, M., Chagnoleau, C., Chevallier, O., Bergoglio, V., Sartori, D., Mavilio, F., Angulo, J.F., Avril, M.F., Sarasin, A.., Larcher, F., Del Rio, M.,  Bernerd, F., Magnaldo, T.
Preclinical corrective gene transfer in xeroderma pigmentosum human skin stem cells.
Mol Ther. 2012, 20(4):798-807.

Grepin R, Guyot M, Jacquin M, Durivault J, Chamorey E, Sudaka A, Serdjebi C, Lacarelle B, Scoazec JY, Negrier S, Simonnet H, Pagès G.
Acceleration of clear cell renal cell carcinoma growth in mice following bevacizumab/Avastin treatment: the role of CXCL cytokines.
Oncogene, 2012, 31(13):1683-94.

Caujolle, J. P., Maschi, C., Freton, A., Pagès, G., and Gastaud, P. (2012)
Treatment of neovascular glaucoma after proton therapy for uveal melanomas with ranibizumab injection: preliminary results,
Ophthalmic Res 47, 57-60.

Ait-El-Mkadem S*, Fragaki K*, Chaussenot A, Gire C, Mengual R, Bonesso L, Bénéteau M, Ricci J-E, Desquiret-Dumas V, Procaccio V, Rötig A, Paquis-Flucklinger V. *Equal participation.
Refractory epilepsy and mitochondrial dysfunction due to GM3 synthase deficiency.
Eur J Hum Genet, in press

Bannwarth S, Figueroa A, Fragaki K, Destroismaisons L, Lacas-Gervais S, Lespinasse F, Vandenbos F, Pradelli LA, Ricci JE, Rötig A, Michiels JF, Vande Velde C, Paquis-Flucklinger V.
The human (MutS Homolog 5) protein localizes to mitochondria and protects the mitochondrial genome from oxidative damage.
Mitochondrion, 12: 654-65 (2012)

Doyen J, Carpentier X, Haudebourg J, Hoch B, Karmous-Benailly H, Ambrosetti D, Fabas T, Amiel J, Lambert JC, Pedeutour F
Renal cell carcinoma and a constitutional t(11;22)(q23;q11.2): case report and review of the potential link between the constitutional t(11;22) and cancer.
Cancer Genet. 2012 Oct 29.

Burel-Vandenbos F, Ambrosetti D, Coutts M, Pedeutour F
EGFR mutation status in brain metastases of non-small cell lung carcinoma.
J Neurooncol. 2012 Oct 2