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IRCAN's scientific goals


When the data on epidemiology and pathophysiology are analyzed, aging is usually perceived as a process that results from the combined influence of constitutional or so-called « genetic » factors, life-style associated factors and external events. Gerontobiology looks into all the specific medical and biological features of aging on the scale of the human body and develops concepts such as « harmonious » aging, « vulnerable » and « hypercatabolic » states, illustrating the highly heterogeneous characteristics of the aging process. The extreme heterogeneity of aging can be illustrated for a given age by a residual life-expectancy that varies considerably from one individual to another and by the onset, or not, of degenerative disorders, especially cardiovascular and neurological diseases, bone and joint disorders, diabetes and also neoplasms, pathologies in which constitutional determinants and other external factors play a role as they do in aging. [Read more...]

 

 

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SCIENTIFIC HIGHLIGHTS

NEWS


*  Pr Paul Hofman's Team published in Plos One (Oct 31st, 2014) an new technique permitting early diagnosis of  lung cancer :

"Sentinel circulating tumor cells allow early diagnosis of lung cancer in patients with chronic obstructive pulmonary disease".

Authors : M Ilie, V Hofman, E Long-Mira, E Selva, JM Vignaud, B Padovani, J Mouroux, CH Marquette, P Hofman.


* Pr Eric Gilson's Team published on Oct  23rd, 2014, in Cell Reports an outstanding

discovery  :

"The telomeric protein TRF2 regulates angiogenesis by binding and activating the PDGFR-beta promoter".

Authors : M El Maï, K-D Wagner, J-F Michiels, D Ambrosetti, A Borderie, S Destree, V Renault, N Djerbi, M-J Giraud-Panis, E Gilson, N Wagner.


DISTINCTION PHD THESIS

Amine Belaid, from the IRCAN Paul Hofman's team, received a price from the PhD Student School of the Nice University for the best thesis realized in 2013. Title : "SQSTM1, une plateforme de signalisation clé contrôlant l'autophagie sélective jusqu'à la reprogrammation tumorale", Director of the thesis : Dr Baharia Mograbi. Nice, September 2014


OUTSTANDING PUBLICATIONS


*Boulter E, *Estrach S, Errante A, Pons C, Cailleteau L, Tissot F, Meneguzzi G, and Féral CC

CD98hc (SLC3A2) regulation of skin homeostasis wanes with age.

J Exp Med., 2013, Jan. 210:173-190.


*Estrach S, *Lee SA, Boulter E, Pisano S, Errante A, Tissot F, Cailleteau L , Pons C, Ginsberg MH, Feral CC

CD98hc (SLC3A2) Loss Protects Against Ras-Driven Tumorigenesis by Modulating Integrin-Mediated Mechanotransduction.

Cancer Research, 2014, in press (*co-first).


J Albrengues, I Bourget, C Pons, V Butet, P Hofman, S Tartare-Deckert, CC Féral, G Meneguzzi, C Gaggioli

LIF Mediates proinvasive activation of stromal fibroblasts in cancer.

Cell Reports, 2014, 7 : 1-5.

D Filipponi, J Muller, A Emelyanov,  DV Bulavin
WIP1 controls global heterochromatin silencing via ATM/BRCA1-dependent DNA
methylation. Cancer Cell, 2013, 24(4):528-41.


Y Zhu, YF Huang, C Kek, DV Bulavin

Apoptosis differently affects lineage tracing of Lgr5 and Bmi1 intestinal stem cell
populations. Cell Stem Cell, 2013, 12(3):298-303.


E Röttinger, P Dahlin, MQ Martindale

A Framework to establish a Cnidarian Gene Regulatory Network for “Endomesoderm” Specification : The inputs of ß-catenin/TCF signaling. PLOS Genetics, 2012, 8 (12), e1003164.

E Röttinger, MQ Martindale

Ventralization of an indirect developing hemichordate by NiCl2 suggest a conserved mechanism in dorso-ventral (D/V) patterning in Ambulacraria (Hemichordates and Echinoderms). Developmental Biology, 2011, 354 (1), 173-190.


Chaussenot A, Le Ber I, Ait-El-Mkadem S, Camuzat A, de Septenville A, Bannwarth S, Genin EC, Serre V, Augé G, The French research network on FTD and FTD-ALS, Brice A, Pouget J, Paquis-Flucklinger V

Screening of CHCHD10 in a French cohort confirms the involvement of this gene in FTD-ALS.

Neurobiology of Aging, 2014, Jul 24.pii: S0197-4580(14)00491-6.


Bannwarth S, Ait-El-Mkadem S, Chaussenot A, Genin EC, Lacas-Gervais S, Fragaki K,  Berg-Alonso L, Kageyama Y, Serre V, Moore D, Verschueren A, Rouzier C, Le Ber I, Augé G, Cochaud C, Lespinasse F, N’Guyen K, de Septenville A, Brice A, Yu Wai Man P, Sesaki H, Pouget J, Paquis-Flucklinger V.

A mitochondrial origin for frontotemporal dementia and amyotrophic lateral sclerosis through CHCHD10 involvement.

Brain, 2014, 137: 2329-2345.