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IRCAN's scientific goals

When the data on epidemiology and pathophysiology are analyzed, aging is usually perceived as a process that results from the combined influence of constitutional or so-called « genetic » factors, life-style associated factors and external events. Gerontobiology looks into all the specific medical and biological features of aging on the scale of the human body and develops concepts such as « harmonious » aging, « vulnerable » and « hypercatabolic » states, illustrating the highly heterogeneous characteristics of the aging process. The extreme heterogeneity of aging can be illustrated for a given age by a residual life-expectancy that varies considerably from one individual to another and by the onset, or not, of degenerative disorders, especially cardiovascular and neurological diseases, bone and joint disorders, diabetes and also neoplasms, pathologies in which constitutional determinants and other external factors play a role as they do in aging. [Read more...]



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On June 25th, 2015, during the annual meeting of the French Sarcoma Group in Bordeaux, Laurence Bianchini and Florence Pedeutour received a price from the "Info-Sarcomes Association" (President Mrs Estelle Lecointe) for their research project : "La voie de signalisation cellulaire FGF/FGFR : une nouvelle cible thérapeutique dans les liposarcomes dédifférencés".

All informations are available on


* The french magazine "La Recherche" published in June 2015 a report on young scientists "under 40 and representing the scientific future of the french research" (La Recherche, N° 500, Juin 2015). Among these scientists, Gaël Cristofari, Team leader at the IRCAN Institute, was cited.

* Mrs Marilena Lupu-Plesu, Marie-Curie Fellow in the team of Gilles Pagès, is in charge of the FP7 Marie-Curie VELYMPH project from the  European Commission :

“Investigation of VEGF-C involvement in the acquired metastatic properties of renal cell carcinoma following anti-angiogenesis treatments”

(Jan 2015 - Dec 2016). More details  

*  Pr Paul Hofman's Team published in Plos One (Oct 31st, 2014) an new technique permitting early diagnosis of  lung cancer :

"Sentinel circulating tumor cells allow early diagnosis of lung cancer in patients with chronic obstructive pulmonary disease".

Authors : M Ilie, V Hofman, E Long-Mira, E Selva, JM Vignaud, B Padovani, J Mouroux, CH Marquette, P Hofman.

* Pr Eric Gilson's Team published on Oct  23rd, 2014, in Cell Reports an outstanding

discovery  :

"The telomeric protein TRF2 regulates angiogenesis by binding and activating the PDGFR-beta promoter".

Authors : M El Maï, K-D Wagner, J-F Michiels, D Ambrosetti, A Borderie, S Destree, V Renault, N Djerbi, M-J Giraud-Panis, E Gilson, N Wagner.


* June 4th, 2015.  DuPont Awards Early Career Grants to Nine Promising University

Research Leaders : Gianni Liti, Chargé de Recherche CNRS and Team Leader at the

IRCAN received the "Dupont Young Professor Award" More Details

Amine Belaid, from the IRCAN Paul Hofman's team, received a price from the PhD Student School of the Nice University for the best thesis realized in 2013. Title : "SQSTM1, une plateforme de signalisation clé contrôlant l'autophagie sélective jusqu'à la reprogrammation tumorale", Director of the thesis : Dr Baharia Mograbi. Nice, September 2014


Hofman P, Cherfils-Vicini J, Bazin M, Ilie M, Juhel T, Hébuterne X, Gilson E, Schmid-Alliana A, Boyer P, Adriouch S, Vouret-Craviari V.

Genetic and pharmacological inactivation of the purinergic P2RX7 receptor dampens inflammation but increases tumor incidence in a mouse model of colitis-associated cancer.

Cancer Res., 2015, in press.

Mimouna S, Bazin M, Mograbi B, Darfeuille-Michaud A, Brest P, Hofman P, Vouret-Craviari V.

HIF1A regulates xenophagic degradation of Adherent and Invasive Escherichia coli (AIEC).

Autophagy, 2014, 10:2333-2345.

Boulter E, Estrach S, Errante A, Pons C, Cailleteau L, Tissot F, Meneguzzi G, and Féral CC

CD98hc (SLC3A2) regulation of skin homeostasis wanes with age.

J Exp Med., 2013, Jan. 210:173-190.

Estrach S, Lee SA, Boulter E, Pisano S, Errante A, Tissot F, Cailleteau L , Pons C, Ginsberg MH, Feral CC

CD98hc (SLC3A2) Loss Protects Against Ras-Driven Tumorigenesis by Modulating Integrin-Mediated Mechanotransduction.

Cancer Research, 2014, in press.

J Albrengues, I Bourget, C Pons, V Butet, P Hofman, S Tartare-Deckert, CC Féral, G Meneguzzi, C Gaggioli

LIF Mediates proinvasive activation of stromal fibroblasts in cancer.

Cell Reports, 2014, 7 : 1-5.

D Filipponi, J Muller, A Emelyanov,  DV Bulavin
WIP1 controls global heterochromatin silencing via ATM/BRCA1-dependent DNA
methylation. Cancer Cell, 2013, 24(4):528-41.

Y Zhu, YF Huang, C Kek, DV Bulavin

Apoptosis differently affects lineage tracing of Lgr5 and Bmi1 intestinal stem cell
populations. Cell Stem Cell, 2013, 12(3):298-303.

E Röttinger, P Dahlin, MQ Martindale

A Framework to establish a Cnidarian Gene Regulatory Network for “Endomesoderm” Specification : The inputs of ß-catenin/TCF signaling. PLOS Genetics, 2012, 8 (12), e1003164.

E Röttinger, MQ Martindale

Ventralization of an indirect developing hemichordate by NiCl2 suggest a conserved mechanism in dorso-ventral (D/V) patterning in Ambulacraria (Hemichordates and Echinoderms). Developmental Biology, 2011, 354 (1), 173-190.

Chaussenot A, Le Ber I, Ait-El-Mkadem S, Camuzat A, de Septenville A, Bannwarth S, Genin EC, Serre V, Augé G, The French research network on FTD and FTD-ALS, Brice A, Pouget J, Paquis-Flucklinger V

Screening of CHCHD10 in a French cohort confirms the involvement of this gene in FTD-ALS.

Neurobiology of Aging, 2014, Jul 24.pii: S0197-4580(14)00491-6.

Bannwarth S, Ait-El-Mkadem S, Chaussenot A, Genin EC, Lacas-Gervais S, Fragaki K,  Berg-Alonso L, Kageyama Y, Serre V, Moore D, Verschueren A, Rouzier C, Le Ber I, Augé G, Cochaud C, Lespinasse F, N’Guyen K, de Septenville A, Brice A, Yu Wai Man P, Sesaki H, Pouget J, Paquis-Flucklinger V.

A mitochondrial origin for frontotemporal dementia and amyotrophic lateral sclerosis through CHCHD10 involvement.

Brain, 2014, 137: 2329-2345.

Bergstrom A, Simpson JT, Salinas B, Barre B, Parts L, Zia A, Nguyen Ba AN, Moses AM, Louis EJ, Mustonen V, Warringer J, Durbin R, Liti G.

New sequencing tools give up close look at yeast evolution.

Mol. Biol. and Evolution, 2014, DOI:10, 1093/molbev/msu037.